End-replication problem (Olovnikov 1971; Hayflick 1965 limit): linear chromosome ends (telomeres) shorten by ~50-200 bp per replication cycle because lagging-strand RNA-primer removal at the chromosome 3' end leaves a 3' overhang that…
End-replication problem (Olovnikov 1971; Hayflick 1965 limit): linear chromosome ends (telomeres) shorten by ~50-200 bp per replication cycle because lagging-strand RNA-primer removal at the chromosome 3' end leaves a 3' overhang that…