The therapeutic index (TI) is the canonical quantitative measure of drug safety margin: the ratio of the dose producing toxicity in 50% of subjects (TD50) to the dose producing the desired therapeutic effect in 50% of subjects (ED50). …
The therapeutic index (TI) is the canonical quantitative measure of drug safety margin: the ratio of the dose producing toxicity in 50% of subjects (TD50) to the dose producing the desired therapeutic effect in 50% of subjects (ED50). …