Linus Pauling's 1946 theorem of enzyme catalysis: enzymes bind the transition state (‡) more tightly than substrate or product; the tighter binding lowers ΔG‡ and accelerates the reaction. Experimental corollary: transition-state analogues…
Linus Pauling's 1946 theorem of enzyme catalysis: enzymes bind the transition state (‡) more tightly than substrate or product; the tighter binding lowers ΔG‡ and accelerates the reaction. Experimental corollary: transition-state analogues…