Ubiquitin (Nobel 2004)

Layer 2 — Chemistryin the bioorganic-chemistry subtree

Hershko-Ciechanover-Rose Nobel 2004 ubiquitin-proteasome: E1-E2-E3 cascade marks K48-poly-Ub for 26S proteasome degradation; basis of PROTAC + cell-cycle.

Related concepts

Tree (graph-theoretic)
v = V·S/(Km+S) at S = Km ⇒ v = V/2 (half-saturation anchor)

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