Urea cycle (ornithine cycle) framework

Layer 3 — Biologyin the Amino Acid And Nucleotide Metabolism subtree

Krebs-Henseleit 1932: 5-step cycle in liver mitochondria + cytoplasm converting NH₃ + CO₂ + aspartate → urea + fumarate. Net stoichiometry: 2 NH₄⁺ + HCO₃⁻ + 3 ATP → urea + 2 ADP + AMP + 4 Pᵢ. Inborn errors (OTC deficiency, citrullinemia)…

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