Waddington epigenetic landscape

Layer 3 — Biologyin the Stem Cells And Development Principles subtree

Waddington 1957: cell fate as ball rolling down branching potential surface V(x) on gene-expression manifold; differentiation = gradient flow ẋ = -∇V(x); reprogramming traverses saddle points uphill. Quasi-potential approximations via…

Related concepts

Explore Waddington epigenetic landscape on the interactive knowledge graph →