Wnt ligand binds Frizzled + LRP5/6, inhibits GSK3β-mediated β-catenin degradation. β-catenin accumulates, enters nucleus, partners with TCF/LEF for target-gene transcription. Drives development + stem-cell maintenance.
Wnt ligand binds Frizzled + LRP5/6, inhibits GSK3β-mediated β-catenin degradation. β-catenin accumulates, enters nucleus, partners with TCF/LEF for target-gene transcription. Drives development + stem-cell maintenance.