Prusiner-Lansbury seeded-nucleation model: misfolded conformer M templates conversion of native monomer N → M via dN/dt = -k₁ N M^n. Lag-and-burst kinetics fit Aβ/α-syn/tau aggregation; explains transmissibility (CJD, BSE) and progressive…
Prusiner-Lansbury seeded-nucleation model: misfolded conformer M templates conversion of native monomer N → M via dN/dt = -k₁ N M^n. Lag-and-burst kinetics fit Aβ/α-syn/tau aggregation; explains transmissibility (CJD, BSE) and progressive…