Lesion-specific DNA glycosylase removes damaged base (8-oxo-G, uracil, alkylated base) creating AP site → AP endonuclease → gap-fill by Pol β → ligation. Short-patch or long-patch variants.
Lesion-specific DNA glycosylase removes damaged base (8-oxo-G, uracil, alkylated base) creating AP site → AP endonuclease → gap-fill by Pol β → ligation. Short-patch or long-patch variants.