Endogenous (hydrolysis, oxidation, alkylation, replication errors) or exogenous (UV, ionising radiation, chemical mutagens) lesions. ~10⁴-10⁵ damage events per cell per day; distinct repair pathways per lesion class.
DNA damage
Related concepts
- Adenine (A)
- Thymine (T)
- Mismatch repair (MMR)
- Base excision repair (BER)
- Nucleotide excision repair (NER)
- Homologous recombination (HR)
- Non-homologous end joining (NHEJ)
- DNA double-strand break (DSB)
- Mutation
- p53 tumor suppressor
- Direct reversal repair
- Translesion DNA synthesis
- Enabling hallmark: genome instability and mutation
- Primary hallmark: genomic instability