Post-replicative correction of base-base mismatches and small indels. MutSα/β recognise lesion; MutLα nicks daughter strand; EXO1 excises; Pol δ + ligase I resynthesise. Loss → Lynch syndrome.
Post-replicative correction of base-base mismatches and small indels. MutSα/β recognise lesion; MutLα nicks daughter strand; EXO1 excises; Pol δ + ligase I resynthesise. Loss → Lynch syndrome.