'Guardian of the genome': transcription factor activated by DNA damage, hypoxia, oncogene stress. Induces cell-cycle arrest (p21), apoptosis (PUMA, BAX), senescence. Mutated in ~50% human cancers.
'Guardian of the genome': transcription factor activated by DNA damage, hypoxia, oncogene stress. Induces cell-cycle arrest (p21), apoptosis (PUMA, BAX), senescence. Mutated in ~50% human cancers.