Gene whose loss-of-function contributes to cancer. Two-hit hypothesis (Knudson 1971): both alleles inactivated. p53, RB, APC, BRCA1/2, PTEN, PTCH1, NF1.
Gene whose loss-of-function contributes to cancer. Two-hit hypothesis (Knudson 1971): both alleles inactivated. p53, RB, APC, BRCA1/2, PTEN, PTCH1, NF1.