Stable cell-cycle arrest with altered morphology, SASP (senescence-associated secretory phenotype), persistent DDR. Triggers: telomere attrition (Hayflick), oncogene, stress. Both tumor-suppressive and aging-related.
Stable cell-cycle arrest with altered morphology, SASP (senescence-associated secretory phenotype), persistent DDR. Triggers: telomere attrition (Hayflick), oncogene, stress. Both tumor-suppressive and aging-related.