Normal somatic cells undergo replicative senescence driven by telomere shortening after ~40-60 divisions (Hayflick limit). Cancer cells escape this clock via (i) telomerase reactivation — TERT promoter mutations and amplification…
Normal somatic cells undergo replicative senescence driven by telomere shortening after ~40-60 divisions (Hayflick limit). Cancer cells escape this clock via (i) telomerase reactivation — TERT promoter mutations and amplification…