Ribonucleoprotein reverse transcriptase (TERT catalytic subunit + TERC RNA template) that extends 3′ telomere overhangs. Active in stem cells/germline/~90% cancers; silenced in most somatic cells.
Ribonucleoprotein reverse transcriptase (TERT catalytic subunit + TERC RNA template) that extends 3′ telomere overhangs. Active in stem cells/germline/~90% cancers; silenced in most somatic cells.