Stable cell-cycle arrest triggered by telomere dysfunction, DNA damage, oncogenic stress, or other insults — with the senescence-associated secretory phenotype (SASP: IL-6, IL-8, MMPs, growth factors) as a hallmark output. Antagonistic:…
Stable cell-cycle arrest triggered by telomere dysfunction, DNA damage, oncogenic stress, or other insults — with the senescence-associated secretory phenotype (SASP: IL-6, IL-8, MMPs, growth factors) as a hallmark output. Antagonistic:…