López-Otín, Blasco, Partridge, Serrano, Kroemer (Cell 2023) update to the original Cell 2013 hallmarks. Twelve interlocking cellular and systemic hallmarks each satisfying three criteria: (i) manifesting during normal aging, (ii)…
Hallmarks of aging (López-Otín 2023)
Related concepts
- Aging biology
- Aging-hallmark tripartite classification
- Primary hallmark: genomic instability
- Primary hallmark: telomere attrition
- Primary hallmark: epigenetic alterations
- Primary hallmark: loss of proteostasis
- Primary hallmark: disabled macroautophagy
- Antagonistic hallmark: deregulated nutrient sensing
- Antagonistic hallmark: mitochondrial dysfunction
- Antagonistic hallmark: cellular senescence
- Integrative hallmark: stem cell exhaustion
- Integrative hallmark: altered intercellular communication
- Integrative hallmark: chronic inflammation (inflammaging)
- Integrative hallmark: dysbiosis
- Geroscience hypothesis