Age-related decline in mitochondrial respiratory capacity, ETC complex abundance, and mtDNA integrity; accumulation of mtDNA heteroplasmy and deletions; reduced mitophagic clearance of damaged mitochondria; aberrant ROS production that can…
Age-related decline in mitochondrial respiratory capacity, ETC complex abundance, and mtDNA integrity; accumulation of mtDNA heteroplasmy and deletions; reduced mitophagic clearance of damaged mitochondria; aberrant ROS production that can…