Sirtuin–NAD⁺ aging axis

Layer 3 — Biologyin the Aging Biology subtree

The seven mammalian sirtuins (SIRT1-7) are NAD⁺-dependent deacylases / ADP-ribosyltransferases controlling chromatin, metabolic, and stress-response programmes. Tissue NAD⁺ pools decline with age (~50% reduction by 50 years in human skin,…

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