Bcl-2 family

Layer 3 — Biologyin the Cell Fate Apoptosis Senescence subtree

Regulators of mitochondrial outer-membrane permeabilisation (MOMP). Anti-apoptotic (Bcl-2, Bcl-xL, Mcl-1); effector (BAX, BAK); BH3-only (BIM, PUMA, BID). Target of venetoclax in CLL.

Related concepts

Intrinsic (mitochondrial) apoptosis

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