Bioorthogonal chemistry: k₂ > 1 M⁻¹s⁻¹, zero biological cross-reactivity

Bioorthogonal chemistry (Bertozzi 2022 Nobel) — reactions that operate in living-cell / whole-organism conditions with two simultaneous constraints: (i) second-order rate k_2 > 1 M⁻¹ s⁻¹ in water at 37 °C (so that at µM probe…