Click chemistry: CuAAC 1,3-dipolar cycloaddition → 1,2,3-triazole

Click chemistry (Sharpless-Meldal-Tornøe 2001 coinage; Sharpless-Meldal-Bertozzi 2022 Nobel) — a modular ligation philosophy defined by four simultaneous constraints: (i) high yield (> 95%); (ii) regio- and stereospecific (single product);…