BRCA/Fanconi anemia pathway

Layer 3 — Biologyin the Dna Repair And Recombination subtree

BRCA1/BRCA2 + FA core complex coordinate HR repair of interstrand crosslinks. Germline mutations predispose to breast/ovarian cancer; synthetic-lethal with PARP inhibitors.

Related concepts

Homologous recombination (HR)
Enabling hallmark: genome instability and mutation
Synthetic lethality in cancer

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