Two gene perturbations are synthetically lethal if each alone is tolerated but their combination kills the cell. Exploited therapeutically in cancer: BRCA1/BRCA2-mutant tumors have lost homologous-recombination repair and are selectively…
Two gene perturbations are synthetically lethal if each alone is tolerated but their combination kills the cell. Exploited therapeutically in cancer: BRCA1/BRCA2-mutant tumors have lost homologous-recombination repair and are selectively…