Caspase cascade (Yuan-Horvitz 1993)

Layer 3 — Biologyin the Cell Fate Apoptosis Senescence subtree

Yuan-Horvitz 1993 ced-3 worm = caspase-1; Nicholson 1995 caspase-3 substrates; initiator + executioner caspases; BIR-domain IAP inhibition; cleave 1000+ substrates.

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