Competitive inhibition framework: K_m^app = K_m·(1 + I/K_i); V_max unchanged

Layer 2 — Chemistryin the bioorganic-chemistry subtree

The competitive-inhibition equation — the canonical modification of the Michaelis-Menten constant in the presence of a competitive inhibitor I that binds reversibly to the free-enzyme active site with dissociation constant K_i. Mechanism:…

Related concepts

Michaelis-Menten v = V·S/(Km+S): steady-state ES kinetics
Competitive inhibition: K_m^app = K_m·(1+I/K_i); at I=K_i ⇒ K_m^app=2K_m; at I=0 ⇒ K_m^app=K_m
Biconditional (IFF)

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