Iron-dependent lipid-peroxidation cell death. Suppressed by GPX4 (selenoprotein) reducing lipid peroxides. Targeting GPX4 or cystine import (system xc-) induces ferroptosis in cancer.
Iron-dependent lipid-peroxidation cell death. Suppressed by GPX4 (selenoprotein) reducing lipid peroxides. Targeting GPX4 or cystine import (system xc-) induces ferroptosis in cancer.