Screens small (MW<300) 'fragments' at high concentration via NMR/SPR/X-ray; hits are fused or grown into lead compounds. Delivered e.g. vemurafenib (melanoma). Rule-of-three (MW<300, logP<3, HBD≤3, HBA≤3) guides library design.
Screens small (MW<300) 'fragments' at high concentration via NMR/SPR/X-ray; hits are fused or grown into lead compounds. Delivered e.g. vemurafenib (melanoma). Rule-of-three (MW<300, logP<3, HBD≤3, HBA≤3) guides library design.