Cancer cells acquire autonomy from homeostatic mitogen control. Mechanisms: autocrine production of growth factors (e.g. PDGF, TGF-α); constitutive activation of receptor tyrosine kinases (HER2 amplification, EGFR mutations);…
Cancer cells acquire autonomy from homeostatic mitogen control. Mechanisms: autocrine production of growth factors (e.g. PDGF, TGF-α); constitutive activation of receptor tyrosine kinases (HER2 amplification, EGFR mutations);…