Three-tier kinase cascade: MAPKKK → MAPKK → MAPK (e.g. Raf → MEK → ERK). Downstream of RTKs via Ras; drives proliferation, differentiation. Aberrant in ~30% cancers.
Three-tier kinase cascade: MAPKKK → MAPKK → MAPK (e.g. Raf → MEK → ERK). Downstream of RTKs via Ras; drives proliferation, differentiation. Aberrant in ~30% cancers.