Single-TM receptors that dimerise on ligand binding, trans-autophosphorylate cytoplasmic Tyr residues recruiting SH2-domain effectors. EGFR, PDGFR, VEGFR, FGFR, insulin-R; major oncogenes.
Single-TM receptors that dimerise on ligand binding, trans-autophosphorylate cytoplasmic Tyr residues recruiting SH2-domain effectors. EGFR, PDGFR, VEGFR, FGFR, insulin-R; major oncogenes.