PI3K-AKT pathway

Layer 3 — Biologyin the Cell Signaling subtree

PI3K phosphorylates PIP2→PIP3; AKT/PKB bound via PH domain, phosphorylated by PDK1 + mTORC2. Drives survival, growth, metabolism. PTEN opposes PI3K; mutated in many cancers.

Related concepts

Receptor tyrosine kinase (RTK)
mTOR pathway

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