mTOR kinase forms mTORC1 (rapamycin-sensitive, growth/metabolism via S6K + 4E-BP1) + mTORC2 (rapamycin-resistant, cytoskeleton + AKT). Integrates amino-acid, growth-factor, energy signals.
mTOR kinase forms mTORC1 (rapamycin-sensitive, growth/metabolism via S6K + 4E-BP1) + mTORC2 (rapamycin-resistant, cytoskeleton + AKT). Integrates amino-acid, growth-factor, energy signals.