Histone acetylation

Layer 3 — Biologyin the Epigenetics And Chromatin subtree

Lysine acetylation (Kac) by HATs (p300, CBP, GCN5) neutralises positive charge, loosens chromatin, recruits bromodomain readers (BET family). Reversed by HDACs. Drug target in oncology (SAHA, romidepsin).

Related concepts

Histone post-translational modification

Explore Histone acetylation on the interactive knowledge graph →