Immune checkpoint (PD-1 / CTLA-4)

Layer 3 — Biologyin the Cancer Biology subtree

Allison-Honjo Nobel 2018: anti-CTLA-4 (Ipilimumab 2011) + anti-PD-1 (Pembrolizumab/Nivolumab 2014) checkpoint inhibitors restore anti-tumor T-cell response; revolutionized melanoma + lung cancer.

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