Induced pluripotent stem cell (iPSC)

Layer 3 — Biologyin the Stem Cells And Development Principles subtree

Somatic cell reprogrammed to pluripotency by ectopic Yamanaka factors (Oct4, Sox2, Klf4, c-Myc). Takahashi-Yamanaka 2006 (mouse), 2007 (human). Nobel 2012. Enabled patient-specific disease modelling.

Related concepts

Embryonic stem cell (ESC)
Yamanaka factors
Yamanaka partial reprogramming rejuvenation

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