Core pluripotency transcription factors OSKM: Oct4, Sox2, Klf4, c-Myc. Sufficient to reprogram fibroblasts to iPSCs; c-Myc replaceable (Nanog, Lin28 alternatives) to reduce tumorigenicity.
Core pluripotency transcription factors OSKM: Oct4, Sox2, Klf4, c-Myc. Sufficient to reprogram fibroblasts to iPSCs; c-Myc replaceable (Nanog, Lin28 alternatives) to reduce tumorigenicity.