Knudson 1971 / Vogelstein 1988: cancer requires sequential acquisition of k driver mutations; cumulative incidence I(t) ∝ t^{k-1} from Armitage-Doll multi-stage model. Predicts age-incidence power-law observed for colorectal/lung/breast…
Knudson 1971 / Vogelstein 1988: cancer requires sequential acquisition of k driver mutations; cumulative incidence I(t) ∝ t^{k-1} from Armitage-Doll multi-stage model. Predicts age-incidence power-law observed for colorectal/lung/breast…