Regulated necrotic-like death via RIPK1-RIPK3-MLKL axis. MLKL oligomerises, translocates to plasma membrane, permeabilises → cell rupture + DAMP release. Inflammatory; pro-inflammatory alternative when CASP8 blocked.
Regulated necrotic-like death via RIPK1-RIPK3-MLKL axis. MLKL oligomerises, translocates to plasma membrane, permeabilises → cell rupture + DAMP release. Inflammatory; pro-inflammatory alternative when CASP8 blocked.