p53 tumor suppressor (Vogelstein 1989)

Layer 3 — Biologyin the Cell Fate Apoptosis Senescence subtree

Vogelstein 1989 p53 mutated in >50% cancers; Lane 1979 SV40-large-T binding; transcription factor for cell-cycle arrest (p21) + apoptosis (Bax) + DNA-repair; MDM2 negative-feedback.

Related concepts

Tree (graph-theoretic)
Hopf bifurcation

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