PROTAC (proteolysis-targeting chimera)

Layer 3 — Biologyin the Systems And Chemical Biology Methods subtree

Bifunctional small molecule linking target protein to E3 ubiquitin ligase → degradation via UPS. Catalytic, event-driven pharmacology — opposite of occupancy-driven. ARV-471, ARV-110 in clinic.

Related concepts

Ubiquitin-proteasome system

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