Ubiquitin-proteasome system

Layer 3 — Biologyin the Cell Signaling subtree

E1 → E2 → E3 cascade appends ubiquitin to substrate (K48-polyUb) for 26S proteasomal degradation. Regulates cell cycle, signalling, MHC-I antigen presentation, quality control.

Related concepts

Ubiquitination
PROTAC (proteolysis-targeting chimera)

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