Covalent attachment of 76-residue ubiquitin via isopeptide bond to Lys side chain. K48 polyubiquitin targets proteasomal degradation; K63 regulates signalling/trafficking.
Covalent attachment of 76-residue ubiquitin via isopeptide bond to Lys side chain. K48 polyubiquitin targets proteasomal degradation; K63 regulates signalling/trafficking.