Hayflick limit emerges from end-replication problem: each S-phase loses Δ ~ 50-100 bp; telomere length L_n = L_0 - n·Δ - σ√n decreases linearly until critical L_c triggers p53/p21 senescence. Simple linear-ODE attrition model (with…
Hayflick limit emerges from end-replication problem: each S-phase loses Δ ~ 50-100 bp; telomere length L_n = L_0 - n·Δ - σ√n decreases linearly until critical L_c triggers p53/p21 senescence. Simple linear-ODE attrition model (with…