Bacterial adaptive-immunity endonuclease repurposed for programmable genome editing. sgRNA guides Cas9 to target; DSB → NHEJ/HR. Jinek-Charpentier-Doudna 2012; Zhang + Church 2013 (mammalian). Nobel 2020.
Bacterial adaptive-immunity endonuclease repurposed for programmable genome editing. sgRNA guides Cas9 to target; DSB → NHEJ/HR. Jinek-Charpentier-Doudna 2012; Zhang + Church 2013 (mammalian). Nobel 2020.