The first genetic longevity pathway identified: *C. elegans* daf-2 (insulin/IGF-1 receptor homologue) loss-of-function doubles lifespan, requiring downstream daf-16/FOXO (Kenyon, Friedman 1988; Kenyon 1993). Conserved in flies (*chico*)…
The first genetic longevity pathway identified: *C. elegans* daf-2 (insulin/IGF-1 receptor homologue) loss-of-function doubles lifespan, requiring downstream daf-16/FOXO (Kenyon, Friedman 1988; Kenyon 1993). Conserved in flies (*chico*)…