PROTAC cooperativity: α = 1 at neutrality; α = 10 at 10-fold positive cooperativity (canonical pins)

Cooperativity evaluations: α = K_d^binary/K_d^ternary at cooperativity-neutral (K_d^binary = K_d^ternary = 1) equals the exact integer 1; at 10-fold positive cooperativity (K_d^binary = 10 with K_d^ternary = 1) equals exact integer 10 —…