PROTAC ternary-complex cooperativity framework: α = K_d^binary / K_d^ternary (E3-target-degrader design metric)

Layer 2 — Chemistryin the chemical-biology subtree

PROTAC (proteolysis-targeting chimera) ternary-complex cooperativity: a bifunctional small molecule recruits an E3 ubiquitin ligase to a target protein, forming a ternary complex T–PROTAC–E3. Cooperativity α is defined as the ratio…

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