Phase I oxidation/reduction/hydrolysis (CYP450 family) introduces polar groups; Phase II conjugation with glucuronide, sulfate, GSH, acetyl. Phase III transporters (P-gp, MRP) efflux. Can bioactivate (acetaminophen → NAPQI) or detoxify.
Phase I oxidation/reduction/hydrolysis (CYP450 family) introduces polar groups; Phase II conjugation with glucuronide, sulfate, GSH, acetyl. Phase III transporters (P-gp, MRP) efflux. Can bioactivate (acetaminophen → NAPQI) or detoxify.